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Clemastine fumarate
Catalog No. T0147Cas No. 14976-57-9
Alias Meclastine fumarate, Meclastine (fumarate), HS-592 (fumarate)
Clemastine fumarate (Meclastine (fumarate)) is a synthetic ethanolamine with anticholinergic, sedative, and histamine H1 antagonistic properties.
Clemastine fumarate
Catalog No. T0147Alias Meclastine fumarate, Meclastine (fumarate), HS-592 (fumarate)Cas No. 14976-57-9
Clemastine fumarate (Meclastine (fumarate)) is a synthetic ethanolamine with anticholinergic, sedative, and histamine H1 antagonistic properties.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 mg | $38 | In Stock | |
| 100 mg | $51 | In Stock | |
| 200 mg | $76 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $50 | In Stock |
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Purity:99.8%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Clemastine fumarate (Meclastine (fumarate)) is a synthetic ethanolamine with anticholinergic, sedative, and histamine H1 antagonistic properties. |
| Targets&IC50 | H1 receptor:3 nM |
| In vitro | In rats, Clemastine Fumarate (5-20 mg/kg) significantly inhibits yeast polysaccharide-induced paw edema and croton oil-induced ear swelling in a dose-dependent manner. |
| In vivo | In HL-60 cells, Clemastine Fumarate (IC50=3 nM) effectively inhibits histamine-induced increases in Ca2+ levels. In the human leukemia cell line K562 and the human B-lymphoblast cell line SB, concentrations of Clemastine Fumarate ≥25 μM significantly suppress both natural killer (NK) cell and antibody-dependent cell-mediated cytotoxicity (ADCC) activities. Additionally, Clemastine Fumarate potently inhibits the HERG K+ channel in HEK 293 cells stably expressing the channel (IC50=12 nM). |
| Alias | Meclastine fumarate, Meclastine (fumarate), HS-592 (fumarate) |
| Molecular Weight | 459.97 |
| Formula | C25H30ClNO5 |
| Cas No. | 14976-57-9 |
Storage & Solubility Information
| Storage | keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 9 mg/mL (19.57 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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